Lack of group-to-individual generalizability

Fisher AJ, Medaglia JD, Jeronimus BF. Lack of group-to-individual generalizability is a threat to human subjects research. Proceedings of the National Academy of Sciences. 2018;115:E6106-E6115.

"This suggests that literatures in social and medical sciences may overestimate the accuracy of aggregated statistical estimates".

I recently gave a
talk on this *big* problem.

Food for thought: a conference (BMJ)

"Nutrition, which is often neglected, is one of the biggest drivers of the global epidemic of chronic lifestyle diseases, including obesity and diabetes. However, the evidence base for dietary advice is beset with poor quality science and unresolved controversy". Conference.

Perils of the NNT

S. Senn. Personal perils: are numbers needed to treat misleading us as to the scope for personalised medicine? (Guest Post)

Bootstrap Inference using boottest

Roodman D, MacKinnon JG, Nielsen MO, Webb MD. Fast and Wild: Bootstrap Inference in Stata Using boottest. Queen’s Economics Department. Working Paper No. 1406

"We review the main ideas of the wild cluster bootstrap, o
er tips for use, explain why it is particularly amenable to computational optimization, state the syntax of boottest, artest, scoretest, and waldtest, and present several empirical examples for illustration"

Study size based on precision

Rothman KJ, Greenland S. Planning Study Size Based on Precision Rather than Power. Epidemiology. 2018

"Focusing on precision may help to avert some of the problems related to reliance on statistical hypothesis testing"

Obesity: Contrary Evidence and Consilience

Archer E, Lavie CJ, Hill JO. The Contributions of Diet, Genes, and Physical Activity to the Etiology of Obesity: Contrary Evidence and Consilience. Prog Cardiovasc Dis. 2018

The "Metabolic Tipping Point" paradigm and the "Maternal Resources Hypothesis" provide comprehensive mechanistic explanatory narratives that answer the two "Fundamental Questions of Obesity".

Supplements for CVD Prevention and Treatment

Jenkins DJA, Spence JD, Giovannucci EL et al. Supplemental Vitamins and Minerals for CVD Prevention and Treatment. J Am Coll Cardiol. 2018;71:2570-2584.

"Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufciency) was not demonstrated"

Big Data and Predictive Analytics

Shah ND, Steyerberg EW, Kent DM. Big Data and Predictive Analytics: Recalibrating Expectations. JAMA. 2018

On the importance of model calibration.

Linear regression and the normality assumption

Schmidt AF, Finan C. Linear regression and the normality assumption. Journal of Clinical Epidemiology. 2018;98:146-151.

Outcome transformations may change the target estimate and hence bias results.

Initial data analysis

Huebner M, le Cessie S, Schmidt C, Vach W. A Contemporary Conceptual Framework for Initial Data Analysis. Observational Studies. 2018;4:171-192.

Proposal of a framework for IDA from the IDA group of the
STRATOS initiative.